Fa'amatalaga
O a matou tofacitinib intermediates e taua tele i le gaosiga o le gaosiga o le tofacitinib, o se vailaʻau lauiloa e faʻaaogaina e togafitia ai nisi ituaiga o gasegase.O lenei vaeluagalemu e iai sona sao taua i le gaosiga o le tofacitinib, e fesoasoani i lona aoga ma le lelei.Via (2R,3R)-2,3-bis [(4-methylbenzoyl)oxy]succinic acid ma le (3R,4R)-N,4-dimethyl-1-(phenylmethyl)- O le tuufaatasiga saʻo o 3-piperidinamines, tatou oloa fa'amautinoa le tu'ufa'atasiga o le tofacitinib maualuga e fetaui ma sili atu i tulaga fa'apisinisi.
Ole fua mole mole ma le mamafa ole tofacitinib intermediate e faʻaalia ai lona mama ma le malosi, ma avea ai ma vaega faʻalagolago i le gaosiga o vailaʻau.Faatasi ai ma ana mea e fuaina ma le faaeteete, o lenei vaeluagalemu e faʻamaonia le tumau ma le aoga o le oloa mulimuli, tofacitinib.O ona uiga mole mole e saofagā foi i le tofacitinib atoa le mautu ma le ola faʻasalaina, faʻamautinoa e tumau le aoga ma faʻatuatuaina mo se taimi umi.
Filifili Matou
O le JDK o lo'o i ai le vaega muamua o le gaosiga o fale ma meafaigaluega tau pulega lelei, lea e fa'amautinoa ai le tu'uina atu o le API intermediates.'Au fa'apolofesa fa'amautinoa le R&D o le oloa.Faʻasaga ia lua, o loʻo matou suʻeina CMO & CDMO i maketi i totonu o le atunuʻu ma faavaomalo.